Definition of the International Normalized Ratio (INR) and its consequences for the calibration procedure of thromboplastin preparations: a rebuttal.
نویسندگان
چکیده
A.M.H .P . VAN D EN BESSELAAR , L . POLLER ,* and A . TR IPODI Haemostasis and Thrombosis Research Center, Department of Haematology, Leiden University Medical Center, Leiden, the Netherlands; *ECAA Central Facility, School of Biological Sciences, The University of Manchester, Manchester, UK; and A Bianchi Bonomi Haemophilia and Thrombosis Center, IRCCS Maggiore Hospital, University of Milan, Milan, Italy
منابع مشابه
Guidelines on preparation, certification, and use of certified plasmas for ISI calibration and INR determination--a rebuttal.
Reliable international normalized ratio (INR) determination depends on accurate values for international sensitivity index (ISI) and mean normal prothrombin time (MNPT). Local ISI calibration can be performed to obtain reliable INR. Alternatively, the laboratory may determine INR directly from a line relating local log(prothrombin time [PT]) to log(INR). This can be done by means of lyophilized...
متن کاملSimplified method for international normalized ratio (INR) derivation based on the prothrombin time/INR line: an international study.
BACKGROUND The need to perform local International Sensitivity Index (ISI) calibrations and in particular the requirement for a manual method for prothrombin time (PT) determination, have proved to be obstacles to application of the WHO scheme for PT standardization. METHODS We used international normalized ratio (INR) derived with a set of only 5 European Concerted Action on Anticoagulation ...
متن کاملEuropean Concerted Action on Anticoagulation. A multicentre calibration study of WHO international reference preparations for thromboplastin, rabbit (RBT/90) and human (rTF/95).
A 10 centre calibration was performed after six years to determine the international sensitivity index (ISI) of rTF/95 relative to RBT/90, and to assess any international normalised ratio (INR) bias compared with the original multicentre calibration. After exclusion of one outlying centre, the follow up calibration gave a mean ISI for rTF/95 of 0.99, which although a small difference, is signif...
متن کاملField study of lyophilised plasmas for local prothrombin time calibration in The Netherlands.
AIM To assess the effect of a lyophilised calibrant plasma procedure on the international normalised ratio (INR) and its interlaboratory variation. METHODS INR equivalent values were assigned to five lyophilised plasmas (one from normal donors and four from coumarin treated patients) by a reference laboratory using three calibrated thromboplastin reagents. The calibrant plasmas and five artif...
متن کاملINR calibration of Owren-type prothrombin time based on the relationship between PT% and INR utilizing normal plasma samples.
Prothrombin time (PT) is clinically important and is used to monitor oral anticoagulant therapy. To obtain PT results in international normalized ratio (INR), the current standardization procedure is complex and involves reference reagents. The PT of diluted plasma samples can be determined with a combined thromboplastin (the Owren-type procedure), but not necessarily with a plain thromboplasti...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Journal of thrombosis and haemostasis : JTH
دوره 2 8 شماره
صفحات -
تاریخ انتشار 2004